LifeTree Hovenia dulcis Berry(Fruit) Extract Powder 

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Clinical Code Name: LB-HD-1, Standardized on Quercetin HPLC(5.9~8.9ug/g) 

Clinically Proven Daily Dosage: 2,460mg, Extract Ratio: 3:1

Certified Triple Functionality by Korea Ministry of Food and Drug Safety (KFDA) in 2008 & 2014*

`May help protect the liver from alcohol damage'. 

`May help relieve fatigue caused by stress'

`May help improve exercise capacity'*

                                        

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Binomial name: Hovenia dulcis Thunb

Efficacy: May support Acute and Chronic alcohol & Non-alcohol induced Liver Dysfunctions*



 

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Biologically Active Compounds for Hepatoprotective Effects in Hovenia.



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The synergistic benefit of a variety of components in the Hovenia extract makes it effective. H. dulcis contains a variety of biologically active compounds (antioxidants, flavonoids) including saponin derivatives, dammarane-type triterpene, hodulosides, and flavonoids hovenodulinol, hovenitins I, II and III, -catechin,(+)-afzelechin, dihydrokaempferol..Quercetin, Taxifolin, Myricetin, Ampelopsin( dihydromyricetin, DHM). *(2)



The 4 major flavonoids in Hovenia dulcis Berry( Fruit ) Extract

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What is DHM ( Dihydromyricetin, Ampelopsin ) Flovonoid and its Sources? 

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 LifeTree scientists identified that DHM(Dihydromyricetin, Ampelopsin) is one of the 4 major flavonoids existing in Hovenia. DHM was known to the public by

a  published article in 2012*(6). The journal stated that `Hovenia dulcis' and`Vine Tea( Ampeolosis Grossedentata)' as DHM`s sources.  

LifeTree Biotech also identified that highly concentrated DHM can be Chirality;  concerning this DHM`s unique Chiral-Chemical Characteristics, the DHM

flavonoid-focused ingredient itself or any concentrated form is Not Considered GRAS( Generally Recognized as Safe) under Natural Health Foods in Korea. 

The article on the DHM*(6) confirmed total flavonoids purified from Hovenia dulcis Tree are 4.53% of the extract, of which DHM accounts for~40%. Specifically, the DHM Content of  Hovenia Berry(Fruit) is intrinsically low because of its unique characteristics: LifeTree`s Hovenia dulcis Berry Extract Powder is Clinically proven for its liver-supporting efficacy*, and its safety was confirmed through long-term stringent Toxicological Evaluation.Highly Effective  , yet Safe and Chiral-Free. 

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Hovenia dulcis Berry`s Long Use History

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                                   Science Papers: Chiefly Pharmacological Botanical,1876 London_page 238 by Daniel Hanbury

The fruit (Berry) of Hovenia dulcis, has long been used in East Asia to reduce alcohol intoxication and treat alcohol poisoning. It does this partly by speeding alcohol metabolism: extracts of the fruit increase the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase.*

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 References : LifeTree`s Published Article _Hovenia dulcis Berry (Fruit) Extract Powder (1-5)

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1. A standardized extract of the fruit of Hovenia dulcis alleviated alcohol induced hangover in health subjects with heterozygous ALDH2: A randomized, controlled, crossover trial; Ewha Wemen`s Univ and  Seoul National Univ._Test Hovenia Material provided by Lifetree Biotech.

2. HPLC Determination of Bioactive Flavonoidsin Hovenia dulcis Fruit Extracts Journal of Chromatographic Science, 2016, Vol. 54, No. 2, 130–135 doi: 10.1093/chromsci/bmv114Advance Access  Publication Date: 2 August 2015Article

3. Anti-fatigue activity of Hovenia dulcis(www.ncbi.nlm.nih.gov/pubmed/23895162. The American journal of Chinese Medicine in 2013

4. Hapatoprotective and blood alcohol lowering effects of fruit peduncle extract of Hovenia dulcis var. Koreana in the in vitro animal models.-Na C S, Chung N C, Yang K H, Kim S H, Chung H S, Dong M S.Yakhak Hoeji 2004

5. Evaluation of Herb Drug Interactions of Hovenia dulcis Fruit Extracts- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421419/ 2017

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 DHM Article

 6. The Journal of Neuroscience, January 4, 2012 #8226; 32(1):390–401 (UCLA)

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*The statements on this website have not been evaluated by the Food and Drug Administration. 

These products are not intended to diagnose, treat, cure or prevent any diseases. 

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