Biologically Active Compounds for Hepatoprotective Effects in Hovenia
The synergistic benefit of a variety of components in the Hovenia extract that make it effective. H. dulcis
contains a variety of biologically active compounds (antioxidants, flavonoids) including saponin derivatives,dammarane-type
triterpene, saponins, hodulosides I – V and flavonoids hovenodulinol, hovenitins I, II and III, (−)-catechin, (+)-afzelechin,
dihydrokaempferol, Quercetin, Toxifolin, Myricetin, Ampelopsin( dihydromyricetin,DHM).* 
--HPLC Determination of Bioactive Flavonoids in Hovenia dulcis Fruit Extracts Journal of Chromatographic Science, Volume 54, Issue 2, 1
February 2016 _LifeTree Biotech R&D-
LifeTree Hovenia`s Proven Efficacy & Best Quality
Korea FDA Certified 2008, 2013 through Clinical Test and Stringent Safety Evaluations
(Standardized on Quercetin with naturally occurring DHM flavonoid)
-Health claims approved by Korea FDA for LifeTree`s Hovenia dulcis berry extract powder-
May help protect liver from alcohol damage.
May help improve exercise capacity.
May help relieve fatigue caused by stress.
History of hovenia use**
K’ung Fu Tzu (Latinized as Confucious) lived from 551–470 BCE, and considered the author Book of Songs.
The book includes 300 traditional songs of the Zhou Dynasty (1066–221 BCE) with hundreds of references to food,
providing an agricultural picture of the age. Book of Songs mentions 44 food plants. Raisin tree (Hovenia dulcis) is
included in the 44 food list as fruits - History of Agricultural and Horticultural Technology in Asia
Professor Jules Janick / Department of Horticulture and Landscape Architecture/ Purdue University* 
What is Hovenia dulcis? * 
-Plant Extract Attenuates the Effects of Alcohol (The Journal of Neuroscience, January 4, 2012)
Fruit of the Japanese raisin tree, Hovenia dulcis, has long been used in East Asia to reduce alcohol intoxication and
treat alcohol poisoning. It does this partly by speeding alcohol catabolism: extracts of the fruit increase the activity of alcohol
dehydrogenase and acetaldehyde dehydrogenase. Additional effects of H. dulcis may make it useful in treating alcohol withdrawal.
Chronic alcohol use reduces GABAergic inhibition, thus producing tolerance and causing withdrawal symptoms
such as anxiety and increased seizure susceptibility.
Hovenia dulcis is listed among the premier anti-hangover herbal medicines in China’s first pharmacopoeia, the Tang
Materia Medica (Su, 659).Hovenia extracts ameliorate alcohol induced liver injuries (Du et al., 2010) and relieves hangover,partly
by promoting EtOH elimination via enhancement of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH)
activity (Kim et al., 2000; Chen et al., 2006).
Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication:*
Here we demonstrate that dihydromyricetin [(2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4- one (DHM)],
a flavonoid component from Hovenia, is highly effective in counteracting acute EtOH intoxication, EtOH exposure/ withdrawal-
induced GABAAR plasticity and AWS symptoms, as well as reducing excessive EtOH consumption. We provide strong evidence that
DHM is a candidate for development as a novel AUD therapy.
-Yi Shen,A. Kerstin Lindemeyer,Claudia Gonzalez, Xuesi M. Shao, Igor Spigelman,Richard W. Olsen, and Jing Liang
Departments of 1Molecular and Medical Pharmacology and 2Neurobiology, David Geffen School of Medicine,
and Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, California 90095 *
Published Scientific Research Atricles by LifeTree Biotech R&D
1. Hapatoprotective and blood alcohol lowering effects of fruit peduncle extract of Hovenia dulcis var. Koreana
in the in vitro animal models.- Na C S, Chung N C, Yang K H, Kim S H, Chung H S, Dong M S.Yakhak Hoeji 2004
2. Anti-fatigue activity of Hovenia dulcis
(www.ncbi.nlm.nih.gov/pubmed/23895162 The American journal of Chinese Medicine in 2013
3. HPLC Determination of Bioactive Flavonoids in Hovenia dulcis Fruit Extracts
Journal of Chromatographic Science, Volume 54, Issue 2, 1 February 2016
4. Evaluation of Herb–Drug Interactions of Hovenia dulcis Fruit Extracts
-Used material: Lifetree Hovenia dulcis extract powder, 2017-
5. A standardized extract of the fruit of Hovenia dulcis alleviated alcohol induced hangover in health subjects
with heterozygous ALDH2: A randomized, controlled, crossover trial –Ewha Wemen`s Univ & Seoul National Univ:
US JOURNALS & MEDIA
6. The Journal of Neuroscience, January 4, 2012 • 32(1):390–401, published by Stanford University*
7. History of Agricultural and Horticultural Technology in Asia by Purdue University**
8. NBC TV Bay Area, Jan 13, 2012- The Buzz Behind the Sobriety Pill
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DHM is one of various flavonoid compounds found in Hovenia dulcis.
Hovenia dulcis and its bioactive compound
Alcohol Detoxification & Hepatoprotective Effects
Common name : Hovenia dulcis, 헛개나무, Raisin Tree, Oriental Raisin Tree, Korean Raisin Tree, Honey Tree
Binomial name: Hovenia dulcis Thunb