Common name : Hovenia , Raisin Tree
Biologically Active Compounds
for Hepatoprotective Effects in Hovenia

- The synergistic benefit of a variety of components in the Hovenia extract( HD-1) that make it effective. H.
dulcis contains a variety of biologically active compounds (antioxidants, flavonoids) including saponin
derivatives, dammarane-type triterpene saponins, hodulosides I – V and flavonoids hovenodulinol ,
hovenitin I, dihydromyricetin (DHM), (−)-catechin, (+)-afzelechin, quercetin, etc.* [ (1), (2), (5)]


-Total flavonoids amont in hovenia
Total flavonoids purified from Hovenia are 4.53% of the extract, of which DHM accounts for ~40%. *[( 5)]



KFDA Certificate on Lifetree`s hovenia  dulcis berry extract powder
(Raisin Tree, Health Functional Raw material)

The Korea Food & Drug Administration approved Lifetree Hovenia dulcis berry extract powder (HD-1) as a
health functional raw material in October 2008 and 2013  by compliance with Article 14 and 15 of the Health
Functional Food Act of Republic of Korea through
years taking human clinical research studies with its
long-term safety evaluation.


Health claims approved by Korea FDA
May help protect liver from alcohol damage*
May help improve exercise capacity*[(3)]
May help relieve fatigue caused by stress* [(3)]



Safety Evaluation on Lifetree Hovenia dulcis extract (HD-1)
- Acute oral toxciity limit test by Biological Test Center, USA
- Biotoxtech for its safety and non-toxic qualities through 2002~2003
Single dose  toxicity study(oral)
Micronucleus test
In vitro Reverse Mutation study
In vitro Chromosomal Aberration study
-  Passed Doping Analysis Test by KIST in 2002
(Korea Institute of Science and Technology)


Bibliography
-
Hovenia Dulcis

(1).  Hovenia Bioactive constiuents -Chemical Compositions of the Genus Hovenia
(2).  Edible Medicinal and Non-Medicinal Plants. Volume 5, Fruits- T.K. Lim
(3).  Anti-fatigue activity of Hovenia dulcis (www.ncbi.nlm.nih.
gov/pubmed/23895162 )The American journal of Chinese Medicine in 2013 by
Lifetree  Biotech R&D
(4)   Hyun TK et al. Hovenia dulcis--an Asian traditional herb.
Planta Med. 2010 Jul;76:943-9. Institute for Plant Sciences, Karl Franzens-
University of Graz, Austria.
(5).  390 • The Journal of Neuroscience, January 4, 2012 •
32(1):390–401,Discussion  page 399
(6).  Plant Extract Attenuates the Effects of Alcohol
(7).  Outlines of Botany in 1835 by Gilbert T. Burnett F.L.S. -Oxford University.
Page 627, plant list # 1965.
(8). History of Agricultural and Horticultural Technology in Asia
by Purdue University

Media on hovenia efficacy by UCLA Researcher
(9). NBC TV Bay Area, Jan 13, 2012- The Buzz Behind the Sobriety Pill


-Rhus Verniciflua Strokes (RVS) extract standardized on Fustin
-2015 Published Research Journals by Liftree Biotech R&D

(1). Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice
(2). A Liquid Chromatography–Tandem Mass Spectrometry Method for
Simultaneous Quantitation of 10 Bioactive Components in Rhus verniciflua
Extracts-Published by Oxford University Press.
*This statement has not been evaluated by the Food and Drug Administration. These products are
not intended to diagnose,treat,cure or prevent any diseases.
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LIFETREE BIOTECH USA,INC.